| abstract |
A pharmaceutical formulation is provided for delivering paclitaxel in vivo comprising: water and micelles comprising paclitaxel and a pharmaceutically-acceptable, water-miscible solubilizer forming the micelles, the solubilizer selected from the group consisting of solubilizers having the general structures n n R.sub.1 COOR.sub.2, R.sub.1 CONR.sub.2, and R.sub.1 COR.sub.2, n n wherein R 1 is a hydrophobic C 3 -C 50 alkane, alkene or alkyne and R 2 is a hydrophilic moiety. The solubilizer is selected such that it does not have a pKa less than about 6. |