| abstract |
Fused polycyclic 2-aminopyrimidines of formula (1) are described: wherein n R 1 is a group --L 1 R 2 where L 1 is a covalent bond or a linker atom or group and R 2 is a group --(Alk) m L 2 R 3 where Alk is an optionally substituted aliphatic or heteroaliphatic chain, m is zero or the integer 1, L 2 is a covalent bond or a linker atom or group and R 3 is an optionally substituted cycloaliphatic or heterocycloaliphatic group provided that when m is zero n L 2 is a covalent bond; n Ar is an aryl or heteroaryl group; n X is a carbon or nitrogen atom; n Y is a carbon or nitrogen atom; n Z is a linker group; n A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group; n and the salts, solvates, hydrates and N-oxides thereof. n The compounds are potent and selective inhibitors of protein kinases, especially src-family protein kinases and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to have a role. |