| abstract |
The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: wherein wavy line attachments indicate either the alpha ( alpha ) or beta ( beta ) configuration; hatched segments indicate a configuration; the solid triangle is used to indicate beta configuration; dashed bonds represent a double bond, or a single bond; R is a substituted heteroaryl radical having at least two pendant substituents selected from the group consisting of C1 to C6 alkyl; halogen; trifluoromethyl; COR1; COCF3; SO2NR1; NO2 and CN or at least one cyano group; R1 is hydrogen or a lower alkyl radical having up to six carbon atoms, X is selected from the group consisting of -OR1 and -N(R1)2; Y is =O or represents 2 hydrogen radicals and the 9, 11 or 15 lower alkyl esters thereof; provided, however, when said heteroaryl radical is a dichlorothienyl radical, the compound is not a 1-carboxylic add or amide thereof. Certain of the compounds represented by Formula I are novel and comprise another aspect of the present invention. |