| abstract |
Compounds of formula (1), (Gibberellins), and their pharmaceutically acceptable derivatives to promote ulcer-healing, healing of surgical wounds or open fractures and treatment of bronchitis or thrombophlebitis in animals including humans or cultivation of skin cell lines in vitro wherein A is COOR, where R is hydrogen, unsubstituted or substituted C1-20 alkyl, allyl, aryl, arylalkyl, amidine, NR4R5 or an unsaturated or saturated ring containing one or more hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur; R4 and R5 may or may not be the same, are hydrogen, or C1-20 alkyl, allyl, aryl, arylalkyl or an unsaturated or saturated ring containing one or more hetero-atoms selected from the group consisting of nitrogen and sulfur; B is hydrogen, hydroxyl, mercaptan, or halogen, or A and B together form a -CO-O- linkage; R1 is hydrogen, hydroxyl, mercaptan, halogen, amino, azido, NR4R5, unsubstituted or substituted C1-20 alkyl, allyl, aryl, arylalkyl, and R2 is methylene, or a divalent hetero-atom. |