| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f84747e8d08b1023763356d0e7d1db68 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-137 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-46 |
| filingDate |
1997-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c18c5a6e210cbc296b09bdda2e65cb6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d38a784ef35eb1a9ddb1e0d27cad7fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_843d7c379d934f109b989fbc37fb50bc |
| publicationDate |
2000-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6110742-A |
| titleOfInvention |
Synthetic antisense oligodeoxynucleotides targeted to AChE |
| abstract |
A synthetic nuclease resistant antisense oligodeoxynucleotide (AS-OND) capable of selectively modulating human acetylcholinesterase production in the central nervous system is provided. In an embodiment the antisense oligodeoxynucleotide can be selected from - 5'ACGCTTTCTTGAGGC 3' SEQ ID No:1, or - - 5'GGCACCCTGGGCAGC 3' SEQ ID No:2. - The present invention also discloses a pharmaceutical or medical composition comprising as active ingredient at least one synthetic nuclease resistant antisense oligodeoxynucleotide capable of selectively modulating human acetylcholinesterase production in the central nervous system in a physiologically acceptable carrier or diluent. The present invention also provides a method to restore balanced cholinergic signaling in the brain in patients in need of such treatment comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one of a synthetic nuclease resistant antisense oligodeoxynucleotide capable of selectively modulating human acetylcholinesterase production in the central nervous system in a physiologically acceptable carrier. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006253913-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8729245-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7074915-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009208480-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6475998-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003216344-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004168208-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7456154-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004016005-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8952143-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006178333-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009281165-A1 |
| priorityDate |
1992-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |