| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16 |
| filingDate |
1992-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_997a7d55e080d3921257d97d0accc5c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a26a50f5f3a577dd02871d22d64bfe56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43e5b4b6df64566a3d0ce00b2708e74b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d870509bb155139171ae4bb1ec9bc85f |
| publicationDate |
2000-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6103238-A |
| titleOfInvention |
Selectively deglycosylated human immunodeficiency virus type 1 envelope vaccines |
| abstract |
Selective deglycosylation of HIV-1 envelope proteins enhances their ability to elicit a protective immune response in people. Glycosylation can reduce or prevent immunological recognition of envelope protein domains. Selective deglycosylation exposes these domains and improves the opportunity for a protective immune response. Deglycosylation which produces substantial conformational changes (as determined by loss of infectivity) should be avoided. Recombinant HIV-1 envelope glycoproteins are generated which have primary amino acid sequence mutation(s) in consensus sequence(s) for N-linked glycosylation (sugar attachment), so as to prevent glycosylation at that site(s). The position of such genetic deglycosylation is important and should be between the C terminus of gp120 and the Cys at the N-terminal side of the cysteine loop containing the hyper-variable region 3 (V3) (this Cys is generally positioned about at residue 296, counting from the N-terminus of gp120). The mutant glycoprotein should be deglycosylated such that the total molecular mass of the mutant gp120 component is less than 90% (more preferably less than 75%) of the corresponding fully glycosylated wild type gp120 component to maximize a useful immune response. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010111687-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11672853-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010247571-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008038286-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107375919-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2586461-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1275716-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8202523-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3072901-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7358334-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004053100-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6936707-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2873423-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8741311-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3069730-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3187585-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1275716-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016122395-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2568289-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004053100-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9920347-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1741720-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005086429-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2848937-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10307475-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012170765-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2679596-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003059799-A1 |
| priorityDate |
1992-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |