| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0bbef4f6fed6600c9dfa488b4f846726 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H3-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H3-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H3-04 |
| filingDate |
1997-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c557cf911f044e745e6f82b0406448b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_267881cf75e4ef398e690aea52412d58 |
| publicationDate |
2000-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6096725-A |
| titleOfInvention |
Methods of using αGal oligosaccharides as immune system targeting agents |
| abstract |
The invention relates to methods for attenuating xenograft rejection in humans and old world monkeys, using oligosaccharides containing a Gal alpha 1-3Gal motif, to neutralize or remove anti- alpha Gal antibodies. The invention additionally relates to methods for site directed activation of the complement cascade or host leukocytes using oligosaccharides containing a Gal alpha 1-3Gal motif to target anti- alpha Gal antibodies. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention. Such compositions contain, as the active ingredient, an oligosaccharide containing a Gal alpha 1-3Gal motif effective in binding anti- alpha Gal antibodies in vivo or ex vivo. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004243250-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008101177-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003129188-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007099823-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008101177-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005208476-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9420770-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009186373-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003175921-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8252902-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010120058-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8450068-B2 |
| priorityDate |
1997-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |