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filingDate 1998-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2000-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6090920-A
titleOfInvention Aminoterminal propeptides of typed 1 procollagen
abstract Aminoterminal propeptide of type I procollagen exists in serum in two forms: classical type I procollagen which is a heterotrimer containing two pro α1-chains and one pro α2-chain of type I procollagen, and an α1-homotrimer type I procollagen containing three identical pro α1-chains. These intact, trimeric aminoterminal propeptides may be isolated without the use of proteolytic enzymes and the resultant propeptides may be used to prepare antibodies specific for the intact trimeric propeptide, having no affinity for the monomeric form of the propeptide. Such antibodies are useful in methods of assaying intact trimeric aminoterminal propeptide of type I procollagen in serum, without false information resulting from inadvertent assay of the monomeric form of the propeptide.
priorityDate 1995-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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