| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6cc5c7e535b2b00fc3de936176be04c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 |
| filingDate |
1999-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c063cee4fac7d60f1b609c3078f0761d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_031ae2cf080c1ad306e00854f2d693f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89089dc3a1f13f0e03d632d4ea30a31b |
| publicationDate |
2000-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6087363-A |
| titleOfInvention |
Use of imidazole and indole compounds as inhibitors of nitric oxide synthase |
| abstract |
Imidazole and indole compounds were found to inhibit neural nitric oxide synthase (bNOS) activity. Nortopsentin-C inhibited bNOS as well as calcineurin activities suggesting that its actions are directed against calmodulin, a co-factor common to these two enzymes. Two indole compounds, as well as dragmacidin-D, inhibited bNOS, but not calcineurin, activity. Murine macrophage viability and induced NOS (iNOS) activity in cultured cells was also unaffected by these compounds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9763947-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007015813-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012080727-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103298460-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103298460-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9789111-B2 |
| priorityDate |
1999-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |