| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36b19bce8760e32c233f01c03e6406f8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-975
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-734
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-81 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
1997-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bd8b5dc40b7121f82714f7376743a52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54e8bafd60c34a8d2272d0df31cc2644
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31c83872c8d55455e407d50b61f1ab30 |
| publicationDate |
2000-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6086879-A |
| titleOfInvention |
Antibody to the syncytiotrophoblast antigen R80K and use thereof |
| abstract |
This invention relates to a method for suppressing the cytotoxic activity of mammalian Natural Killer (NK) cells, especially in women experiencing repeated miscarriages. An antibody which binds to an 80 kDa surface protein on the maternal surface of normal term human syncytiotrophoblast (R80K) was discovered. This antibody was also found to bind to Natural Killer (NK) target cells (K562) and inhibit NK killing of this human NK target cell line. A monoclonal antibody (BA11) was raised against K562 cells which was also directed against a monomorphic site on the R80K surface protein of placentae. BA11 was found both to inhibit the attachment of NK cells and killing of both target cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7667241-B1 |
| priorityDate |
1995-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |