| abstract |
PCT No. PCT/JP97/04527 Sec. 371 Date May 17, 1999 Sec. 102(e) Date May 17, 1999 PCT Filed Dec. 10, 1997 PCT Pub. No. WO98/25919 PCT Pub. Date Jun. 18, 1998A compound, a pharmaceutically acceptable salt thereof, or a hydrate thereof having PGD2-antagonistic activities, inhibitory activities against infiltration of eosinophils, and being useful as a drug for treating diseases, such as systemic mastocytosis and disorder of systemic mast cell activation, as well as tracheal contraction, asthma, allergic rhinitis, allergic conjunctivitis, urticaria, ischemic reperfusion injury, inflammation and atopic dermatitis, which is shown by the following formula (I): is provided |