| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9b442f17c57e6903e584b8486085ac9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10362
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10322 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-93 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate |
1997-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c66bf4ea1546a85fce7844aede6b2bcc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80de8ef2f6282d628a0659e459bec0f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1659f4c883b0e485c5be72000bec213
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d95953dd253d2e8024e7129fb46c771e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48b135e1c82baf4164b2d9585157ff91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c820851af535e0ae76ed70fee12451cb |
| publicationDate |
2000-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6080578-A |
| titleOfInvention |
Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia |
| abstract |
Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9175309-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009175830-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10080774-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005074430-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012207711-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11065285-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10238698-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005053581-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003138405-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6551587-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005002965-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6638762-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003021768-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10391183-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005260162-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005036989-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7285414-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004101825-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004202663-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9061055-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11155599-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7785887-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004241857-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6764674-B1 |
| priorityDate |
1996-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |