| abstract |
PCT No. PCT/JP97/01746 Sec. 371 Date Nov. 16, 1998 Sec. 102(e) Date Nov. 16, 1998 PCT Filed May 26, 1997 PCT Pub. No. WO97/45135 PCT Pub. Date Dec. 4, 1997A stable pharmaceutical composition of brain derived neurotrophic factor (BDNF) in the form of an aqueous solution or lyophilized one being suitable for a long-term storage, which contains a surfactant, especially nonionic surfactant (e.g., Tween 80) of 0.001 to 10%, whereby the polymerization and the denaturation of BDNF are inhibited, and the biological activities of BDNF are maintained for a long time. The lyophilized composition can be made more stable by addition of a sugar alcohol (e.g., mannitol) and/or an amino acid (e.g., glycine). |