| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0306 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate |
1997-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65936613c149a6166d0979e7b9bf7620
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0090e04cea294d3264a67d5056a1064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_051810ad31b3e41007e24d971ededd83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_047f3df69aaf5586032e207f88d24832
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ddfa9924ea72187ad9406036db5e712 |
| publicationDate |
2000-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6077667-A |
| titleOfInvention |
Method for chromosomal rearrangement by consecutive gene targeting of two recombination substrates to the deletion endpoints |
| abstract |
The present invention involves the creation of defined chromosomal deficiencies, inversions and duplications using Cre recombinase in ES cells transmitted into the mouse germ line. These chromosomal reconstructions can extend up to 3-4 cM. Chromosomal rearrangements are the major cause of inherited human disease and fetal loss. Additionally, translocations and deletions are recognized as major genetic changes that are causally involved in neoplasia. Chromosomal variants such as deletions and inversions are exploited commonly as genetic tools in organisms such as Drosophila. Mice with defined regions of segmental haploidy are useful for genetic screening and allow accurate models of human chromosomal diseases to be generated. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004042007-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113564205-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005160490-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8877435-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003180267-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004033596-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004170614-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005142658-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004042007-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7208317-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7842792-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03048329-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6524818-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113564205-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03048329-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7846718-B2 |
| priorityDate |
1996-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |