| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d595ec481a2a081fed4aa2fd4ff52d8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-32 |
| filingDate |
1997-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a681df41cd5ce638b657c545865e7d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f00a0810c5864cab2c312046747e01d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76379fac3138490e8e6e3b613da7e810 |
| publicationDate |
2000-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6074640-A |
| titleOfInvention |
Enhancement of tumor cell radiosensitivity using single chain intracellular antibodies |
| abstract |
The present invention provides a method of enhancing the chemosensitivity and radiosensitivity of a neoplastic cell expressing an oncoprotein that stimulates proliferation of the cell, comprising introducing into the cell a nucleic acid molecule encoding an antibody homologue, wherein the antibody homologue is expressed intracellularly and binds to the oncoprotein intracellularly in the endoplasmic reticulum of the cell. The present invention is also directed to a method for enhancing the inhibition of proliferation of a neoplastic cell expressing an oncoprotein that stimulates proliferation of the cell, comprising the steps of: introducing into the cell a nucleic acid molecule encoding an antibody homologue, wherein the antibody homologue is expressed intracellularly and binds to the protein intracellularly; and contacting said cell with an anti-neoplastic agent. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6552005-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003104402-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0156604-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009136487-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6703375-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013204069-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6468547-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003148984-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006276379-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7098302-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8129356-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012014965-A1 |
| priorityDate |
1997-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |