| abstract |
The present invention relates to compounds of formula (I), wherein R is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, which groups are optionally substituted by hydroxy, C 1-4 alkoxy or NR a R b , where R a and R b each independently repesent hydrogen or C 1-4 alkyl; or R is C 1-4 alkyl substituted by Ar, and optionally further substituted by one or both of R 4 and R 5 ; R 1 , R 2 and R 3 represent a variety of substituents; R 9 and R 10 are each hydrogen, halogen, C 1-6 alkyl, CH 2 OR c , oxo, CO 2 R a or CONR a R b where R c represents hydrogen, C 1-6 alkyl or phenyl; X is --CH 2 , or --CH 2 CH 2 --; Y is --CH--, --CH 2 --, --CH 2 CH-- or --CH 2 CH 2 --, with the proviso that the sum total of carbon atoms in X+Y is 2 or 3; and when Y is --CH-- or --CH 2 CH--, the broken line is a double bond; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, anesis and postherpetic neuralgia. ##STR1## |