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filingDate 1995-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2000-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1038928dae28647fedee4bee0766a01
publicationDate 2000-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6051434-A
titleOfInvention Activated protein C resistance test
abstract The method for determining functional activity of protein C in a human plasma sample includes incubating the human plasma sample with exogenous reagents that activate factor V and a common pathway of the blood coagulation mechanism through factor X, with activated exogenous protein C and with components that are necessary for efficient clotting of the human plasma sample, or incubating the human plasma sample with exogenous reagents that induce the presence of thrombin in a factor V dependent manner, with activated exogenous protein C and with components that are necessary for efficient clotting of the human plasma sample; monitoring a reaction indicative of a potential rate of coagulation of the plasma sample and comparing the resulting potential rate of coagulation with an equivalent rate for normal patient, or comparing the resulting potential rate of coagulation with an equivalent rate determined for the plasma sample in the absence of activated exogenous protein C; and determining the functional activity of the free protein C from this comparison.
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priorityDate 1994-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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