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filingDate 1996-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2000-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6051218-A
titleOfInvention Tumor radiosensitization using gene therapy
abstract The invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The invention also provides a method of radiosensitizing a tumor in a subject by administering, at a site other than the tumor, a cell genetically modified to express a cytokine. The invention further provides a method of reducing the severity of a cancer in a subject by administering a cytokine at the site of the tumor or by immunizing the subject at a site other than the tumor with tumor cells genetically modified to express a cytokine, and treating the tumor with radiotherapy.
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