| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b9036c33bbe3f4ea428655b76200f7c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-734
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-867 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-464
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
1996-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2000-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ad52fb4db77e3198fd2fd4bed8003e3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_045b8818c62817bc420a19784de9d367
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_942e6b3cbe8caa23268233261ae03eaa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8437995695b67aec6d042cedd0bcd7c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72510013585d16b68f76303001a1db87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c77936fce552d2606835f91c46d9f71 |
| publicationDate |
2000-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6042828-A |
| titleOfInvention |
Humanized antibodies to ganglioside GM2 |
| abstract |
Chimeric human antibody expression vectors are constructed by inserting the antibody heavy chain variable region-encoding cDNA and antibody light chain variable region-encoding cDNA isolated from hybridomas producing a mouse or rat monoclonal antibody reacting with the ganglioside GM2 respectively into an expression vector for use in animal cells which contains the human antibody heavy chain constant region- or human antibody light chain constant region-encoding cDNA. The expression vectors are introduced into animal cells and the transformant thus obtained is cultured for the production of a chimeric human antibody reacting with the ganglioside GM2. In contrast to mouse monoclonal antibodies, the chimeric human antibodies of the invention will not cause anti-mouse immunoglobulin antibody production in the patient's body but shows a prolonged blood half-life, with a reduced frequency of adverse effects, so that it can be expected to be superior to mouse monoclonal antibodies in the efficacy in the treatment of human cancer, for instance. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7935338-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7902339-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011212022-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014220003-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6423511-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8444972-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006263374-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006275307-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6872392-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007048324-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007031423-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015123654-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9066929-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004126378-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7781212-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7781569-B2 |
| priorityDate |
1992-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |