http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6040149-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2400-50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate | 1997-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de252b6e2701f578a78208664cb6bf34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_779faa993631e55a730b9ad9e1bc3244 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a7f0d7dd05c5b1516a8a05ae472ab77 |
| publicationDate | 2000-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6040149-A |
| titleOfInvention | Assay for identifying agents which act on the ceramide-activated protein kinase, kinase suppressor of ras, and methods of using said agents |
| abstract | The subject invention provides a purified membrane-bound ceramide-activated protein kinase having an apparent molecular weight of about 110 kD as determined by SDS polyacrylamide gel electrophoresis, which protein kinase is capable of specifically phosphorylating the threonine residue in a Thr-Pro- or a Thr-Leu-Pro-containing polypeptide. The subject invention also provides a method of determining whether an agent is capable of specifically inhibiting the phosphorylation activity of the ceramide-activated protein kinase. The subject invention further provides a method of determining whether an agent is capable of specifically stimulating the phosphorylation activity of the ceramide-activated protein kinase. The subject invention further provides a method of treating a subject having an inflammatory disorder. The subject invention further provides a method of treating a human subject infected with HIV so as to reduce the proliferation of HIV in the human subject. The subject invention further provides a method of treating a subject having a disorder associated with poor stem cell growth. The subject invention further provides a method of determining whether an agent is capable of specifically inhibiting the ability of lipopolysaccharide to stimulate the phosphorylation activity of the ceramide-activated protein kinase of the subject invention. Finally, the subject invention provides a method of treating a subject suffering from a lipopolysaccharide-related disorder. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004033711-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004033711-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003017535-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003109466-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006019325-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10577613-B1 |
| priorityDate | 1996-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1659.