| abstract |
A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided herein are nucleic acids encoding naturally occurring amino acid sequence variants of NT-4, designated NT-4 beta , NT-4 gamma , and NT-4 DELTA . The neurotrophic factors of the invention are useful in the treatment of nerve cells and in diagnostic assays. |