| abstract |
A two-component fibrin glue for human application includes a) a component A containing i) a virus-inactivated and concentrated cryoprecipitate that contains fibrinogen, and ii) tranexamic acid or a pharmaceutically acceptable salt, thereof; and b) component B containing a proteolytic enzyme that, upon combination with component A, cleaves, specifically, fibrinogen present in the cryoprecipitate of component A, thereby, effecting a fibrin polymer. |