http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6017706-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-811 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 1997-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1235d6f9c342b21673cf9434bdf85fa3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41018e43df4eb6f0389de2467ccd266b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61bcd5c71172d9b25dfd996517814925 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed495dd1ba485f453c82389d5c6a255a |
| publicationDate | 2000-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6017706-A |
| titleOfInvention | Process for identifying compounds which protect against the formation of fluorescent light induced DNA lesions and x-ray-induced lesions |
| abstract | Processes for detecting compounds which protect against fluorescent light-induced DNA lesions, in particular DNA lesions which are induced by oxygen free radicals, are disclosed. The methods of the present invention encompass modifying G1-phase test and/or G2-phase tests so that a compound which is suspected of being capable of protecting against the formation of fluorescent light-induced DNA lesions (i.e., a suspected "DNA protectant"), such as an anti-oxidant or free-radical scavenger, is added to the cell cultures prior to irradiation of the cell cultures with fluorescent light or x-rays. Addition of a DNA protectant to cultures of human skin fibroblasts or PHA-stimulated blood lymphocytes significantly reduces the frequency of radiation-induced chromatid breaks so that there is a small, preferably no, statistical difference in the frequency of radiation-induced chromatid breaks in Alzheimer disease cells in the presence or absence of caffeine in the G1-phase test using fluorescent light, or in normal cells in the presence or absence of ara-C in the G2-phase test using fluorescent light or x-rays. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007264672-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010028258-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6723548-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2106808-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2106808-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8790620-B2 |
| priorityDate | 1997-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.