http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6015895-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_347f5b16ef154303f0a9ca79da9a6638 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-11 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| filingDate | 1996-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_036c113e61e121a1b080d477ce22d54f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0489dd2189abe4d8f80a0861ee60598f |
| publicationDate | 2000-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6015895-A |
| titleOfInvention | Linker arm for solid support oligonucleotide synthesis and process for production thereof |
| abstract | PCT No. PCT/CA96/00837 Sec. 371 Date Jun. 19, 1998 Sec. 102(e) Date Jun. 19, 1998 PCT Filed Dec. 13, 1996 PCT Pub. No. WO97/23497 PCT Pub. Date Jul. 3, 1997A linker arm for solid support oligonucleotide synthesis, the linker arm comprising formula (1), wherein: X1 is selected from the group consisting of -O-, -S-, -S(O)2-, -C(O)- and -N(R12)-; R12 is selected from the group comprising hydrogen, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkaryl group, X3 is -O- or -N(H)-; R1, R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, halide, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group; n is 0, 1 or 2; and one of A' and B' is selected from the group consisting of hydrogen, halide, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group, and the other of A' and B' has formula (2), wherein X2 is selected from the group consisting of -O-, -S-, -S(O)2- and -N(R13)-; R13 is selected from the group comprising hydrogen, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkaryl group; R6 and R7 are the same or different and are selected from the group consisting of hydrogen, halide, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group; p is 0 or 1; and m is 0, 1 or 2. A process for producing the linker arm is also disclosed. The linker arm is useful in solid support oligonucleotide synthesis and is characterized by a desirable combination of stability against spontaneous hydrolysis and ease of intentional cleavage of the synthesized oligonucleotide from the linker arm. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9303055-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10000518-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008318806-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7135564-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3067359-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7553958-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7544638-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011170075-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8053187-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9969761-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005214298-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8461317-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010093974-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010029930-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7211654-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003120035-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003138363-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003162160-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7807807-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007287832-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2048149-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7491680-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003092062-A1 |
| priorityDate | 1995-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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