| abstract |
A naphthyloxyacetic acid derivative of the formula (I) wherein R1 is H, alkyl, alkylene-(-COOR10, -OH, -CONR4R5, -CONR6-alkylene-OH, -NR4R5, -cyano or -tetrazolyl); A is single bond, alkylene, alkenylene, -S-alkylene, -O-alkylene; B is NR3CO, CONR3; R2 is (1) alkyl (2) alkenyl, (3) alkyl or alkenyl substituted by 1-3 of phenyl, cycloalkyl, naphthyl and heterocyclic ring containing nitrogen atom (the said ring may be substituted by 1-3 of alkyl, alkoxy and halogen etc.), (4) NR7R8 or (5) alkylene-NR7R8; non-toxic salt thereof, non-toxic acid addition salt thereof and hydrate thereof can bind the PGE2 receptor and exhibits the activity to antagonize or agonize for PGE2., therefore, they are useful as PGE2 antagonist or PGE2 agonist. |