| abstract |
PCT No. PCT/FR91/00949 Sec. 371 Date Sep. 29, 1992 Sec. 102(e) Date Sep. 29, 1992 PCT Filed Nov. 29, 1990 PCT Pub. No. WO92/09629 PCT Pub. Date Jun. 11, 1992A new chemotactic cytokine, NC28 or Monocyte Chemotactic Protein-3 (MCP-3), is provided. Fragments of the cytokine comprising its 13 C-terminal amino acids also exhibit chemotactic activity. The polypeptides may be used as anticancer agents or immunomodulators. DNA encoding the NC28/MCP-3 polypeptides, as well as corresponding vectors and recombinant expression systems, are also provided. |