| abstract |
Described herein are compounds selective for a 5-HT1D-like receptor, which have the general formula: wherein A is selected from a six-membered, non-aromatic, optionally substituted carbocycle and a six-membered, non-aromatic, optionally substituted heterocycle having one or two heteroatoms selected from O, S, SO, SO2 and N4; R1 is selected from H and OH; n is 0 or 1 as permited by chemical structure; R2 is selected from CR5CR6CH2NR7R8 or a group of formula II, III or IV: R3 is selected from H and benzoyl; R4 is selected from H, loweralkyl, benzyl, loweralkylcarbonyl, loweralkylaminocarbonyl, loweralkylaminothiocarbonyl, loweralkanoyl, loweralkylaminoimide and loweralkoxy-substituted loweralkylene; R5 and R6 are independently selected from H, loweralkoxy and hydroxy; R7 and R8 are independently selected from H and loweralkyl or R7 and R8 form an alkylene bridge which, together with the nitrogen atom to which they are attached, creates an optionally substituted 3- to 6-membered ring; denotes a single or double bond; and R9, R10 and R11 are independently selected from H and loweralkyl. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of a 5-HT1D-like receptor is implicated, such as migraine. |