abstract |
The present invention relates to compounds of formula (I), wherein carbons 1 and 2 are joined by either a single or a double bond; R1 is hydrogen or methyl; R2 is hydrogen or methyl; R3 is (B) wherein X, R6, R7 and R8 are various groups, and pharmaceutically acceptable solvates thereof and their use in the treatment of androgen responsive and mediated diseases. |