| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-32 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-21 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40 |
| filingDate |
1996-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1999-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44cc9946411a08d38a24f8f942aee947
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bbc2b93e67148411feaa22c1489ca8e |
| publicationDate |
1999-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5994583-A |
| titleOfInvention |
Two step synthesis of D- and L- α-amino acids and D- and L- α-amino-aldehydes |
| abstract |
D- and L-α-amino acids and D- and L-α-amino aldehydes are synthesized from olefin substrates in two steps. The first step is a catalyzed asymmetric aminohydroxylation addition reaction to the olefin substrate. The addition reaction is catalyzed by osmium and is co-catalyzed by chiral ligands. The chiral ligands, in addition to being co-catalysts with the osmium, also serve to direct the addition reaction regioselectively and enantioselectively. Divalent ligands are preferred over monovalent ligands because of their enhance regio- and enantio-selectivity. As an oxidant nitrogen source for the addition reaction, either a carbamate or sulfonamide may be employed. If carbamate is employed as an oxidant nitrogen source, the resultant β-hydroxycarbamate is deprotected to yield the corresponding β-hydroxyamine. If sulfonamide is employed as an oxidant nitrogen source, the resultant β-hydroxysulfonamide is deprotected to yield the corresponding β-hydroxyamine. The resultant β-hydroxyamine is then selectively oxidized in a second synthetic step to produce the desired D- and L-α-amino acid or D- and L-α-amino aldehyde. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0114315-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6350905-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6596870-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987504-B2 |
| priorityDate |
1996-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |