http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5990309-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa206d5abb07311badcc825b0af7ebbd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-073 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-06 |
| filingDate | 1999-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e87b0ffa7547b10efae03d09ecba7469 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be9bbc7c45f8f6626bf11dca4a5085eb |
| publicationDate | 1999-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5990309-A |
| titleOfInvention | 2-chloro-5-fluoro-4-morpholinonitrobenzene and 2-chloro-5-fluoro-4-morpholinoaniline |
| abstract | The present invention relates to a process for the preparation of N-carboxyalkyl-3-fluoro-4-dialkylaminoanilines, which comprises reacting, in a first step, an ortho-nitrochlorobenzene of the formula (1) in which X is Cl or F, with a secondary amine of the formula (2) HNR 1 R 2 , in which R 1 and R 2 , independently of one another, are identical or different and are an alkyl radical having from 1 to 10 carbon atoms or, together with the N atom to which they are bonded, form a ring having from 3 to 7 members, in the presence of a base in the presence or absence of a solvent at from -10 to 120° C., reacting, in a second step, the 2-chloro-4-dialkylamino-5-fluoronitrobenzene with hydrogen at from 30 to 150° C. and from 1 to 100 bar in the presence of a base and a noble-metal catalyst and, in a third step, extracting the 3-fluoro-4-dialkylaminoaniline from the reaction mixture using an aqueous solution of an acid as a salt dissolved in water, removing the aqueous phase and reacting the 3-fluoro-4-dialkylaminoaniline salt, dissolved in water, with a chloroformate of the formula (3) ClCO 2 R 3 , in which R 3 is an alkyl radical having from 1 to 10 carbon atoms or an aralkyl radical having from 7 to 20 carbon atoms, at from 0 to 100° C. in the presence of a basic compound. |
| priorityDate | 1997-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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