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publicationDate 1999-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5989826-A
titleOfInvention Nuclear matrix protein fluid assay
abstract Disclosed are methods for determining the degree of cell death in a tissue by detecting and quantitating soluble interior nuclear matrix proteins and protein fragments in body fluids and extracellular media. The methods are is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of interior nuclear matrix proteins and protein fragments in soluble form from cells.
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