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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-09
filingDate 1992-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1999-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe0c514156fcb645cd4a3c09168c6f82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a90a28c813b007ba3caffbe2d722b13
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publicationDate 1999-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5986095-A
titleOfInvention Enantioselective preparation of halophenyl alcohols and acylates
abstract A process is described for preparing a compound of the formula or the S-enantiomer thereof, wherein: R is alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl, R1 is halogen; R2 is halogen, alkyl, cycloalkyl, aryl or wherein the process comprises treating the associated racemic alcohol with an acylating agent (wherein L is a leaving group) and an enzyme or microorganism capable of enantioselective acylation. This process may also be used to isolate the unreacted R- or S-alcohol. The acylated product may be enantioselectively hydrolyzed with a lipase or lipase-supplying microorganism to the S- or R-alcohol. Compounds prepared by this invention are useful antipsychotic agents or useful intermediates therefor.
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