| abstract |
Methods and compositions are disclosed that are useful for the inhibition of glial cell proliferation by means of binding inhibiting agents to neural cell adhesion (N-CAM) molecules present on the cell surface. Such inhibiting agents can be peptides derived from the homophilic binding region of N-CAM, monoclonal antibodies, polyclonal antibodies, Fab' fragments, and the like. Exemplary N-CAM homophilic peptides are 7 to 90 amino acid residues having a positively charged amino acid residue separated from a negatively charged amino acid residue by five intervening amino acid residues. |