Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f47c750954e13a1ed0be96c1bf1c51c7 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1132 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate |
1997-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
1999-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81faeaa2980cdbdb9d9b6db84807f7d8 |
publicationDate |
1999-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-5985661-A |
titleOfInvention |
Anti-HIV ribozymes |
abstract |
Ribozymes targeted against two portions of the HIV-1 genome were designed to cleave HIV RNA in the tat gene (TAT) or in a common exon for tat and rev (TR). The ribozymes were cloned into the LN (LTR-neomycin) retroviral vector plasmids and expressed as part of viral LTR-driven transcripts. The vectors were packaged as amphitropic virions and used to transduce human T-lymphocytes. Expression of the vector transcripts containing the ribozyme sequences were readily detected by Northern blot analysis of the transduced T cells. The T-lymphocytes expressing the anti-HIV-1 ribozymes showed resistance to HIV-1 replication. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8785718-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8309791-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012170765-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7919583-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3072901-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3069730-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2848937-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007031380-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010146655-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03093473-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2568289-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2873423-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2679596-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3187585-A1 |
priorityDate |
1994-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |