| abstract |
A prodrug of the formula (I): where R1 is a group such that the compound R1NH2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): a prodrug of the formula (II): where R2 is a group such that the compound R2OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions. |