| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bc5292a07e34d16eb1d033a16d3aec3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 |
| filingDate |
1997-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1999-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d560050ae1478138f0646c6ae284cb0d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02beb1b670c6897e4628aafb871224f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53c2ec3ae97e393d4256216af79ff9e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7368dd4728d9b271c32460adec8c5fd4 |
| publicationDate |
1999-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5976875-A |
| titleOfInvention |
Diacylglycerol kinase isoforms epsilon and zeta and methods of use thereof |
| abstract |
Two novel diacylglycerol kinase (DGK) isoforms are disclosed. The cDNA of one DGK isoform, designated DGK epsilon , is about 2.6 kb in length. The DGK epsilon cDNA has an open reading frame encoding 567 amino acids and has a predicted molecular mass of 63 kDA. DAG kinase epsilon is highly selective for arachidonate-containing diacylglycerol (DAG) substrates. The cDNA of the second isoform, designated DGK zeta , is 3.5 kb in length. The DGK zeta cDNA contains a single large open reading frame encoding a 928-amino acid protein with a predicted molecular mass of 103.9 kDa. An alternatively spliced muscle specific species of DGK zeta , DGK zeta -2 is also disclosed and characterized. DGK zeta is localized to the nucleus. A lysine-rich region with homology to the MARCKS protein is shown to be necessary and sufficient to confer nuclear localization to DGK zeta via a protein kinase C phosphorylation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02077177-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007161072-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006100152-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0146252-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1546377-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6255095-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02077177-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03073983-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03073983-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004002513-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004132124-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004002513-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1546377-A4 |
| priorityDate |
1996-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |