http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5973142-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1892 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 |
| filingDate | 1998-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_909bfb0d74d570e6d5b13cb49506909d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_366dcfa25f1ce54b7755352dcc91277c |
| publicationDate | 1999-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5973142-A |
| titleOfInvention | Process for synthesizing carbapenem intermediates |
| abstract | A process of synthesizing a compound of formula 1: ##STR1## wherein P and P' each independently represent H or a protecting group, R 1 represents H or C 1-4 alkyl, and n Hal represents a halogen selected from Cl, Br and I, comprising: reacting a compound of formula 2: ##STR2## wherein P, P' and R 1 are as defined above with an N,O-di-C 1-4 alkyl hydroxylamine in the presence of a carbodiimide to produce a compound of formula 3: ##STR3## reacting compound 3 with a compound of formula 4: n n MetCH.sub.2 SiR.sub.2 R.sub.3 R.sub.4 4 n n wherein Met represents lithium or halomagnesium; n R 2 , R 3 and R 4 are C 1-4 alkyl or C 1-4 alkoxy, and the halo portion of halomagnesium is Cl, Br or I, to produce a compound of formula 5: ##STR4## and reacting compound 5 with a halogenating agent to produce a compound of formula 1. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10695322-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011224426-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8841444-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011048583-A1 |
| priorityDate | 1997-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.