http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5962442-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 |
| filingDate | 1996-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cb99a60c39931855ee885f715734559 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ff28c04b3361f0c6ba7b16639eb4544 |
| publicationDate | 1999-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5962442-A |
| titleOfInvention | Irreversible inhibition of human 5α-reductase |
| abstract | PCT No. PCT/US96/00528 Sec. 371 Date May 5, 1997 Sec. 102(e) Date May 5, 1997 PCT Filed Jan. 2, 1996 PCT Pub. No. WO96/20713 PCT Pub. Date Jul. 11, 1996The invention concerns the treatment of hyderandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5 alpha -reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5 alpha -reductase enzyme, NADPH. Until the present invention, it was not know or predicted that 3-oxo-4-azasteroids having 1,2-double bond would form a complex with NADPH by the mechanism of 5 alpha -reductase in vivo. The invention further relates to the novel inhibitor-cofactor complex and pharmaceutical compositions containing the complex. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1955700-A2 |
| priorityDate | 1995-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 163.