| abstract |
Combinatorial chemical libraries of the Formula [S]-C(O)-L'-Z containing biaryl amino acids are disclosed, in which [S] represents a solid support and -L'-Z is a linker/compound residue. In these libraries, Z is -NR1R2. R1 is chosen from H, C1 to C20 hydrocarbon, heteroaralkyl, heterocycloalkyl, substituted arylalkyl, alkoxyalkyl or alkyl-SO2NH-alkyl and R4 is an acyl or sulfonyl residue. R2 is chosen from The combinatorial libraries are optionally encoded with tags. The use of these libraries in assays to discover biologically active compounds is also disclosed. |