| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ffe2c98ce513b7d819e9f1bd18b44b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5cf811e10ad9068ddf72c04b69c8ba8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
1997-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1999-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6ec19078e07e25cf0f148ca3cba5817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d68267f9e5dc0c2b4934606398b078d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84c9ae4185de71892b2fb8528ee1d269
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f48ffaa647462ba553067754d7df4a7d |
| publicationDate |
1999-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5942395-A |
| titleOfInvention |
Hybrid ribozymes and methods of use |
| abstract |
New hybrid ribozymes that exhibit the high metabolic stability of small nucleolar ribonucleic acids (snoRNAs), and that cleave target sequences with high efficiencies in either cis (intra-molecular) or trans (inter-molecular) configuration are described. The hybrid ribozymes include (i) a ribozyme catalytic sequence; and (ii) a snoRNA stabilizing motif; wherein the catalytic sequence and the stabilizing motif are arranged to provide the RNA molecule with a three-dimensional configuration in which the catalytic sequence is positioned to interact with a target sequence and the stabilizing motif adopts a conformation that stabilizes the RNA molecule, and additionally enables the RNA molecule to localize in the nucleolus of a cell. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009307788-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8227442-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007021361-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014011860-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004209353-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010261278-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005048519-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011046208-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7785782-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004214263-A1 |
| priorityDate |
1997-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |