| abstract |
The present invention relates to a method for predicting the tendency of a protein to form amphiphilic α or β structure, wherein a series of values for U are calculated for spans of x residues, where the equation n n U.sub.αx =H.sub.x +μ.sub.αx -<pt> n n is used to predict regions of amphiphilic α structure and the equation n n U.sub.βx =H.sub.x +μ.sub.βx <pt> n n is used to predict regions of amphiphilic β structure, and where H x is the average hydrophobicity for a span of x residues, μ x is the hydrophobic moment, and <pt> is the position dependent turn propensity. When the values for U.sub.αx and U.sub.βx are represented graphically, peaks are predicted to represent regions of α and β structure, respectively. |