| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A40-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-43504
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-967 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K61-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K63-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K63-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74 |
| filingDate |
1996-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1999-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fa6d75772212a66daf59d878b12839c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d9043b2741108c3b6a83709cfc3112c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f026568bc4ffdca8f4d8cfee3af5a1b5 |
| publicationDate |
1999-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5932436-A |
| titleOfInvention |
Daphnia reproductive bioassay for testing toxicity of aqueous samples and presence of an endocrine disrupter |
| abstract |
The invention provides a 6-day Daphnia reproductive bioassay for detecting and confirming the presence of a toxic substance in an aqueous sample, and/or for screening the substance as an endocrine disrupter. According to the assay, a test sample is brought into contact with at least three adult, oviporous Daphnia of a single clone under conditions of crowding and suboptimal growth conditions to cause stress and stimulate sexual reproduction. The preferred clone for use in the assay is Daphnia galeata-mendotae Wingra clone CDF-1. The bioassay is based upon the measurement of five endpoints that convey quantitative information about the biological activity of the substance: survivorship, numbers of female offspring, numbers of male offspring, number of resting eggs, and number of offspring that display developmental deformities. Also provided are kits for use in conducting the bioassay. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106538481-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108037218-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11714076-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102014018936-B3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10267782-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016196729-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1311156-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1311156-A4 |
| priorityDate |
1996-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |