http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5917087-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ad66884a6f2a66126d492e56e09be39 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-14 |
| filingDate | 1995-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85234d3cc9989dee36f00df65149f305 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49189b4e72d1604f63fc5367510bdc80 |
| publicationDate | 1999-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5917087-A |
| titleOfInvention | Process for producing sodium 1-thyroxine comprising the oxidative coupling of a diido-1-tyrosine catalysed by a manganese salt in the presence of an amine |
| abstract | PCT No. PCT/EP95/04017 Sec. 371 Date Apr. 7, 1997 Sec. 102(e) Date Apr. 7, 1997 PCT Filed Oct. 12, 1995 PCT Pub. No. WO96/11904 PCT Pub. Date Apr. 25, 1996Improvements to a six stage process for production of sodium l-thyroxine from l-tyrosine [described in U.S. Pat. No. 2,889,363 and U.S. Pat. No. 2,889,364 (Baxter)] are described, the improvements comprising the oxidative coupling of a diiodo-l-thyrosine to form a biphenyl ether derivative, catalysed by a manganese salt in which the amine and acid functionally of the diiodo-l-thyrosine have been protected by suitable protecting groups, characterised in that the reaction is performed at a pressure of about 20 atmospheres in the presence of an organic amine additive using a gaseous oxidant comprising oxygen and optionally an inert diluent. The process optionally further comprises acid hydrolysis of the biphenyl ether derivative with hydrochloric acid to form a l-thyroxine hydrochloride salt and generation of sodium-l-thyroxine from the l-thyroxine hydrochloride salt. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006008512-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03057717-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03057717-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018007466-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102199103-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015011573-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9428444-B2 |
| priorityDate | 1994-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 138.