| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45a3703d03a4b21be619937f5ad63b8b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1276 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99 |
| filingDate |
1995-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1999-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc2d64cd9b4ef990abe849e7215fbb57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1149964eadffa80db85914596285d6bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a5e93df53e84a55b071dc71f151eceb |
| publicationDate |
1999-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5917033-A |
| titleOfInvention |
Structure based design of inhibitors of HIV-1 reverse transcriptase |
| abstract |
The present invention pertains to a method for designing inhibitors of enzyme human immunodeficiency virus type 1 reverse transcriptase which comprises the steps of: (a) providing a three dimensional model of the receptor site in the prepolymerization complex of the p66 subunit of enzyme human immunodeficiency virus type 1 reverse transcriptase and a known nonnucleoside inhibitor; (b) locating the conserved residues in the p66 subunit which constitute the nonnucleoside inhibitor binding pocket; and (c) designing a new nonnucleoside inhibitor which possesses complementary structural features and binding forces to the residues in the p66 subunit nonnucleoside inhibitor binding pocket. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6653081-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0196611-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004067487-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004063191-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7579143-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006094020-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005214750-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005214752-A1 |
| priorityDate |
1995-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |