| abstract |
PCT No. PCT/GB96/00965 Sec. 371 Date Oct. 7, 1997 Sec. 102(e) Date Oct. 7, 1997 PCT Filed Apr. 18, 1996 PCT Pub. No. WO96/33165 PCT Pub. Date Oct. 24, 1996Compounds of formula (I), wherein X is a -CO2H or -CONHOH group; R4 is a group -CHRxRy wherein Rx and Ry independently represent optionally substituted phenyl or monocyclic heteroaryl rings, which optionally may be linked covalently to each other by a bond or by a C1-C4 alkylene or C2-C4 alkenylene bridge; and R1, R2, R3 and R5 are as defined in the specification are selective inhibitors of stromelysin-1 and matrilysin relative to human fibroblast collagenase and 72 KDa gelatinase. |