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filingDate 1997-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1999-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2c7449030377a1bc7b1406874031389
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publicationDate 1999-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5886217-A
titleOfInvention Method of producing aryl-substituted, amino-acylated phosphonic-acid derivatives with the aid of metal complexes of chiral, amphiphilic ligands
abstract The invention is relates to a method of producing aryl-substituted, amino-acylated phosphonic-acid derivatives with the aid of metal complexes of chiral amphiphilic ligands in that according to the invention alpha -N-acyl-protected, beta -substituted alkene phosphone derivatives are asymmetrically hydrogenated in the presence of a chiral rhodium catalyst in a solvent or a suspension. The use of the micelle-forming catalyst makes possible the hydrogenation of unsaturated phosphonic-acid derivatives in water with a high reaction rate with the obtainment of very good enantiomeric excesses.
priorityDate 1996-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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