| abstract |
Guanidine derivatives of formula I ##STR1## wherein R 8 represents hydrogen, halogen, alkyl C1 to 6, nitro, trifluoromethyl, thioalkyl C1 to 6, hydroxy, alkoxy C1 to 6, or a group selected from --NR 4 R 5 , --O(CH 2 ) p Q, --(CH 2 ) m OQ, --(CH 2 ) m NR 1 R 2 , --O(CH 2 ) m NR 1 R 2 , --NHCO(CH 2 ) m NH(CH 2 ) n Q or --(CH 2 ) p CONR 1 R 2 , or R 8 represents the group A--CO--B; R 9 represents hydrogen, halogen, alkyl C1 to 6, nitro or trifluoromethyl; n and R 1 , R 2 , R 4 , R 5 , n, m, p, Q, A, B, and W are as defined in the specification, are described together with processes for their manufacture and compositions containing them. Compounds of formula I are useful in therapy. |