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filingDate 1996-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1999-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30a4c1ff4ec6ed2e48544320558029c5
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publicationDate 1999-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5885966-A
titleOfInvention Peptide, immunogenic composition and vaccine or medical preparation, a method to immunise animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
abstract PCT No. PCT/NL96/00223 Sec. 371 Date Dec. 5, 1997 Sec. 102(e) Date Dec. 5, 1997 PCT Filed Jun. 6, 1996 PCT Pub. No. WO96/40755 PCT Pub. Date Dec. 19, 1996The invention relates to a modified tandem LHRH-peptide vaccine preparation in which the amino acid glycine at position (6) of one or both LHRH decapeptides that constitute the tandem unit is substituted by a dextrorotatory amino acid that contains a side chain to whicha carrier compound can be coupled. In addition, the tandem LHRH-peptide can be brought into a tandem-dimer form which is also suitable for producing a vaccine that is effective against LHRH (luteinizing hormone releasing hormone) also referred to as GnRH (gonadotropin-releasing hormone), for immunological castration, to inhibit or affect reproductive functions or to affect behaviour in vertebrates in general and in domesticated animals and man in particular.
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