| abstract |
The present invention provides novel compounds and pharmaceutical compositions comprising such compounds useful for treating cystic fibrosis cells, wherein such compounds have the formula <IMAGE> wherein (a) R1 and R3 are methyl, R7 is ethyl or cyclopropylmethyl, and R8 is cyclohexyl; (b) R1 and R3 are allyl, R7 is hydrogen and R8 is cyclohexyl, cyclohexylmethyl, or cycloheptyl; (c) R1 is allyl and R3 is methyl, R7 is hydrogen, and R8 is cyclohexyl; or (d) R1 is methyl, R3 is allyl, R7 is cyclopropylmethyl or ethyl, and R8 is cyclohexyl. |