http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5876697-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7a7a09af9b61106edbb9555a0375abf |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-223 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 |
| filingDate | 1995-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a00892d7c17507eb81c59b8ff7f9af7 |
| publicationDate | 1999-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5876697-A |
| titleOfInvention | Method for the production of microbubble-type ultrasonic contrast agent using fatty acid surfactants |
| abstract | An imaging agent for ultrasound to be administered into a vein is provided. More specifically, an imaging agent for ultrasound containing microbubbles, which has a long-life and is stable within a human body even after is has passed through a lung, and a method for producing the same, are provided. n A method for producing an imaging agent for ultrasound comprises a mixing step wherein a mixture of water, Sodium Stearate, Saponin and CaCl 2 and gas are mixed by a homogenizer for forming bubbles, and a separation step wherein bubbles having a desired size are separated according to their buoyancy after the mixing step. The mixing step further includes two stages, i.e., a low speed mixing stage and a high speed mixing stage. In the low speed mixing stage, a shaft of the homogenizer is immersed into a solution containing a preset amount of Sodium Stearate, Saponin, and CaCl 2 , which is mixed at a low rotation speed for a given period of time and is then left for a given period. Then, such a process is repeated. In the high speed mixing stage, said solution is mixed for a given period at a high rotaion speed. After this 2-stage mixing step, the separation is performed by using a burette, thereby obtaining microbubbles of a desired size. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003167006-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6986740-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7632400-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008029459-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005019264-A1 |
| priorityDate | 1994-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.